Cisapride

From Academic Kids

Cisapride chemical structure
Cisapride

cis-4-amino-5-chloro-N-[1-
[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-
2-methoxybenzamide
CAS number
81098-60-4
ATC code
A03FA02
Chemical formula C23H29ClFN3O4
Molecular weight 465.9
Bioavailability ~100%
Metabolism hepatic, intestinal
Elimination half life 10 hours
Excretion renal, biliary
Pregnancy category B1 (Australia)
Legal status Schedule 4 (Australia)
Delivery tablets, suspension

Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It is sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.).

Clinical uses

Cisapride increases muscle tone in the esophageal sphincter in people with gastroesophageal reflux disease. It also increases gastric emptying in people with diabetic gastroparesis. It has been used to treat bowel constipation.

In many countries it has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias.

Sources

  • Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
  • Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4
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